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Sherri Y. Huang, Jer-Yen Yang, in Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy (Second Edition), 2018 The SHH signaling pathway regulates substantial processes in the development of the CNS.
Where does the palmitoylation reaction take place in Sonic hedgehog?
The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER. Attachment of palmitate to Hh proteins is independent of cholesterol modification and autoprocessing and is catalyzed by Hhat (Hedgehog acyltransferase).
Where does sonic hedgehog get its protein from?
Sonic hedgehog (Shh) is a glycoprotein molecule that is expressed throughout the central nervous system (CNS). It is important during neurodevelopment, particularly through its induction of endogenous neural precursor cells and neural stem cells.
Last Update: Oct 2021
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